A medical wire head-end joint spheroidization apparatus and manufacturing method thereof are disclosed, the medical wire includes a center wire and the winding wire winding outside the center wire, the head ends of the center wire and the winding wire are jointed and subjected to a spheroidization process, the jointing and spheroidization apparatus is to set up the wire clamping mechanism and the welding torch holding mechanism having the axial adjustment mechanism on a platform, the wire clamping mechanism is provided with a wire clamp, and the wire clamp is linked to a lifting mechanism, the welding torch holding mechanism has a torch holder, and an inverted microplasma welding torch with a nozzle upwardly corresponding to the wire clamp is held on the torch holder, and during the joint spheroidization, the wire clamp is first used to clamp the wire, and the wire head-end protrudes by an appropriate distance, followed by using the axial adjustment mechanism to perform alignment correction for the microplasma torch arc tip and the wire center, then the lifting mechanism is used to descend the wire for performing the microplasma welding mode, and after the wire head-end is melt with reducing spheroidization, the lifting mechanism is driven to ascend the wire rapidly, and the wire can be made into a jointing spheroidization head-end after cooling, thus effectively enhancing the production efficiency and jointing quality of wire joint spheroidization.