Non-aqueous, ethanol-free taxane nanodispersion formulations are provided. Nanodispersion formulations of embodiments of the invention include a taxane, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid component, wherein the organic acid component is soluble in the non-aqueous solvent and the amount by weight of non-ionic surfactant is equal to or greater than the amount by weight of non-aqueous solvent. Alos provided are non-aqueous, ethanol-free docetaxel nanodispersion formulations. Nanodispersion formulations of embodiments of the invention include docetaxel, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid which is soluble in the non-aqueous solvent and is substantially free of any conjugate base. Also provided are methods of using the nanodispersion formulations, as well as kits that include the nanodispersion formulations.本發明提供不含乙醇的非水性紫杉烷奈米分散調配物。本發明的具體實例之奈米分散調配物包括紫杉烷、油、非離子性界面活性劑、非水性溶劑及有機酸組份,其中有機酸組份可溶於非水性溶劑中且以重量計的非離子性界面活性劑量等於或大於以重量計的非水性溶劑量。亦提供不含乙醇的非水性歐洲紫杉醇(docetaxel)奈米分散調配物。本發明的具體實例之奈米分散調配物包括歐洲紫杉醇、油、非離子性界面活性劑、非水性溶劑及可溶於非水性溶劑且實質上不含任何共軛鹼之有機酸。亦提供奈米分散調配物之使用方法,以及包括奈米分散調配物之套組。
