The United States of America as represented by the Secretary of Agriculture;Icahn School of Medicine at Mount Sinai;St. Jude Children's Research Hospital
发明人:
申请号：
EP17209515.0
公开号：
EP3332803A1
申请日:
2005.06.01
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
This invention provides a genetically engineered attenuated swine influenza virus, wherein the virus comprises a swine influenza virus NS1 gene with a mutation that results in a swine influenza virus NS1 protein carrying a deletion within its carboxy-terminus. The invention also provides a composition comprising said genetically engineered attenuated swine influenza virus. Additionally, a genetically engineered swine influenza virus is provided for immunization of a pig or prevention of a disease or symptom associated with swine influenza virus. The invention also provides a cultured cell or an embryonated egg containing said genetically engineered attenuated swine influenza virus and a method for production of an immunogenic composition or a pharmaceutical composition.
