Provided is a local, topical, spot-on formulation for control of Indoxacarb-sensitive ectoparasites on a domestic animal comprising an ectoparasitically effective amount of Indoxacarb and a veterinarily acceptable carrier； wherein the concentration of Indoxacarb in said formulation is at least 100g/L； wherein said veterinarily acceptable carrier comprises a crystallization inhibitor and a solvent； wherein said solvent is selected from the group consisting of a glycol ether and an alkyl acetate； wherein Indoxacarb-sensitive ectoparasites consist of parasites, in any stage of life, that live on the outside of an animal's body； and wherein the formulation is applied to an area less than or equal to 10% of the total surface area of the animal's body to effectively control i ndoxacarb-sensitive ectoparasites.
