A pharmaceutical formulation of therapeutically effective amounts of acetaminophen,ibuprofen, and a sympathomimetic drug, such as pseudoephedrine (or its prodrug),or phenylephrine used in the treatment of cold and flu-like symptoms. Such symptomsmay include fever, pain, nasal congestion, sinus congestion, runny nose, sorethroat, myalgia, ear pressure and fullness, and headache. The formulation furtherincludes various excipients used in the formulation process.