Jeffrey A. HUBBELL,Jun ISHIHARA,Ako ISHIHARA,Kazuto FUKUNAGA,Melody SWARTZ
申请号：
US16606539
公开号：
US20200123228A1
申请日:
2018.04.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.
