The present invention provides the purposes of a kind of inhibition S100A16 or the pharmaceuticals for inhibiting the ribonucleic of S100A16 and HSP27 performance what to prepare treatment retinal degenerative diseases. The present invention separately provides a kind of composition with what treatment retinal degenerative diseases, and it includes the ribonucleics for inhibiting S100A16 and HSP27 performance. The present invention separately provides medical composition and purposes including aforementioned composition and its pharmaceutically acceptable carrier. It, can effective protection photoreceptor and recovery retinal function by of the present invention when individually inhibiting S100A16 gene or the gene of S100A16 and HSP27 being inhibited to show simultaneously.本發明提供一種抑制S100A16、或抑制S100A16與HSP27表現的核醣核酸用於製備治療視網膜退化性疾病之醫藥品之用途。本發明另提供一種用於治療視網膜退化性疾病的組合物，其包含抑制S100A16與HSP27表現的核醣核酸。本發明另提供包括前述組合物及其醫藥上可接受的載劑的醫藥組合物與用途。藉由本發明所述之單獨抑制S100A16基因、或同時抑制S100A16與HSP27的基因表現時，能有效保護光感受器與恢復視網膜功能。
