Beadle, John William,Fisher, Kerry,Wilkinson Blanc, Christine
申请号：
AU2020201101
公开号：
AU2020201101A1
申请日:
2020.02.14
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020201101A120200305.pdf#####Abstract The present disclosure provides a method of treating a human patient comprising the steps of: systemically administering multiple doses of a parenteral formulation of a replication capable oncolytic adenovirus of subgroup B in a single treatment cycle, wherein the total dose given in each dose is in the range of 1x10 10 to 1x10 14 viral particles, and wherein each dose of virus is administered over a period of 1 to 90 minutes, for example at a rate of viral particle delivery in the range of 2x101° particles per minute to 2x10 12 particles per minute. The disclosure further extends to formulations of the said oncolytic adenoviruses and combination therapies of the viruses and formulations with other therapeutic agents.
