Salk Institute For Biological Studies;Celldex Therapeutics, Inc.
发明人:
申请号：
EP16180137.8
公开号：
EP3184121A2
申请日:
2013.07.23
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The invention provides a TAM receptor agonist for use in a method of treating an autoimmune disease in a subject, wherein the TAM receptor agonist comprises a phosphatidyl serine (PtdSer) -containing lipid bilayer membrane with Gas6 and/or Protein S bound to the membrane, wherein signaling from one or more TAM receptors is activated. The invention further provides a composition comprising a PtdSer-containing membrane having a Gas6 and/or Protein S protein bound to said membrane. Further provided is a method for classifying a virus as susceptible to anti-TAM therapy and a method of identifying an agent that blocks virus infectivity.
