A non-invasive imaging system, including an imaging scanner suitable to generate an imaging signal from a tissue region of a subject under observation, the tissue region having at least one substructure； a signal processing system in communication with the imaging scanner to receive the imaging signal from the imaging scanner； and a data storage unit in communication with the signal processing system, wherein the data storage unit stores an anatomical atlas comprising data encoding spatial information of the at least one substructure in the tissue region, and a pathological atlas corresponding to an abnormality of the tissue region, wherein the signal processing system is adapted to automatically identify, using the imaging signal, the anatomical atlas, and the pathological atlas, a presence of the abnormality or a pre-cursor abnormality in the subject under observation.
