CALDERWOOD DAVID J.,WILSON NOEL S.,COX PHILIP,HOEMANN MICHAEL Z.,CLAPHAM BRUCE,MULLEN KELLY D.,VASUDEVAN ANIL,VILLAMIL CLARA I.,LI BIN,SOMAL GAGANDEEP
申请号：
ARP110103722
公开号：
AR083358A1
申请日:
2011.10.11
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
It contains bioactive salts, metabolites, toxicological products, raccoon, isopropene, isopropene isomer, diazepine, solution and acceptable hydrate of medicament. Formula compounds (1) can be used as Quinza inhibitors and therefore can be used to treat certain diseases, especially inflammation and diseases, as well as diffuse diseases and disorders, such as, Cancer. Requirements 1: a compound (1) with formulation properties, having pharmaceutically acceptable salts, bioactive metabolites, toxicology, racemization, and corresponding isomers,Troposphere, solution and hydrate, where R1 is n (R) (RB),-CH (Ra) (Rb)-C (Ra) 3DCH (Rb)-C C (Rb)-ORb -C (O) Rb -C (O) N (Ra) -Rb -N (Ra) C (O) -Rb-or -SRb； where Ra is H, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, or optionally substituted C2-6 alkynyl； and Rb is optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C3-6 cycloalkyl； optionally substituted C1-6 alkylene-optionally substituted C3-6 cycloalkyl, optionally substituted C5-12 saturated or partially unsaturated bridge cycloalkyl, optionally substituted C6-10 aryl, optionally substituted C2-10 saturated or partially unsaturated bridge heterocyclyl, C1- heterocyclyl 10 saturated or partially unsaturated optionally substituted,Selective replacement of C1-6 asphalt-c1-10 saturated or partially unsaturated non-n-octanoic acid substitute, selective replacement of C1-10 non-n-octanol, selective replacement of C1-6 non-n-octanol C1-10； Or RA and Rb together form a saturated or partially unsaturated c3-12 carbohydrate ring alternative replacement, a saturated or partially unsaturated C2-10 heterocyclic alternative replacement, and an optional C1-10 heterocyclic ring, A saturated or partially unsaturated c5-12 ringThe saturated or partially unsaturated c5-10 ring is replaced, the saturated or partially unsaturated c5-12 ring is replaced, or the partially or partially unsaturated C2-10 ring bridge ring is repla
