A syringe comprising a cylinder and a plunger arranged in the latter has a sealing element which, with a contact region, abuts an inner wall of the cylinder and seals an annular gap between the plunger and an inner wall of the cylinder. The contact region has a front section which, in the rest state, abuts the inner wall of the cylinder with an abutment pressure. The plunger is connected to the sealing element in such a way that the sealing element does not follow an initial movement of the plunger out of the rest state and such that the sealing element follows a continued movement of the plunger. The abutment pressure between the sealing element and the inner wall in the front section of the contact region decreases during the initial movement. With the syringe, less force is required in order to overcome the static friction between the sealing element and the inner wall of the cylinder.
