The present invention is directed to a composition comprising a carrier and metallic nanoparticles for use in the treatment of acne. The metallic nanoparticles are delivered into openings on or near a skin surface, such as hair follicles, pores and/or into sebaceous glands. This can be achieved by using an apparatus to direct a substance into the openings under pressure via one or more nozzles or slits. A portion of the sebum present in the hair follicle is optionally heated and/or removed, e.g. using low-pressure conduit located on the lower surface of the apparatus, before introducing the metallic nanoparticles.