YEON YOUNG EUN,연영은,KIM YOUNG JU,김영주,HAN BEOM KU,한범구,KIM HYUN IL,김현일,PARK CHARL SE,박철세
申请号：
KR1020170180928
公开号：
KR1020190079031A
申请日:
2017.12.27
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to a novel bacteriophage CS4 having specific killing activity to Cronobacter sakazakii； an antibiotic composition, a feed additive composition, a feed, a disinfectant, a detergent, or a food composition comprising the bacteriophage； a preparation method for Cronobacter sakazakii-free foods, comprising the step of treating a food with the bacteriophage CS4； and a method for preventing or treating infectious diseases caused by Cronobacter sakazakii, comprising the step of administering the bacteriophage to a non-human subject. The method for preventing or treating infectious diseases caused by Cronobacter sakazakii by using the bacteriophage CS4 shows extremely high specificity to Cronobacter sakazakii compared to other chemicals such as existing antibiotics, and the bacteriophage CS4 infects Cronobacter sakazakii and replicates within the Cronobacter sakazakii, thereby showing excellent bacteriolytic activity. In addition, the bacteriophage CS4 of the present invention does not infect other hosts than bacteria, such as humans, animals, and plants, and thus has the advantages of addressing the problems associated with antibiotics-resistant bacteria due to misuse and overuse of antibiotics, antibiotics remaining in foods, and a broad host range. Accordingly, the bacteriophage CS4 of the present invention can be widely used in the fields relating to the prevention or treatment method for infectious diseases caused by Cronobacter sakazakii in non-human subjects, antibiotic compositions, feed additive compositions, feeds, disinfectants, detergents, or food compositions.본 발명은 크로노박터 사카자키(Cronobactersakazakii)에 특이적인 사멸능을 갖는 신규 박테리오파지 CS4, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 세척제 또는 식품 조성물, 상기 박테리오파지 CS4를 식품에 처리하는 단계를 포함하는 크로노박터 사카자키균이 제거된 식품 제조 방법 및 상기 박테리오파지를 인간을 제외한 개체에 투여하는 단계를 포함하는 크로노박터 사카자키에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. 본 발명의 박테리오파지 CS4를 이용한 크로노박터 사카자키에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 크로노박터 사카자키에 대한 특이성이 매우 높고, 상기 박
