Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);Alberto Baldi;Laboratorio Pablo Cassara SRL
发明人:
Baldi, Alberto,Gongora, Adrian Daniel,Mldovan, Alejandro Gustavo
申请号：
AU2015254498
公开号：
AU2015254498A1
申请日:
2015.05.04
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
Murine and humanized anti-human VEGF antibodies and uses are disclosed. The anti- human VEGF antibodies of the invention have higher binding affinity for human VEGF-A, are stronger inhibitors of the VEGF-A induced proliferation of endothelial cells in culture as compared with anti-human VEGF antibodies in the art. Moreover, these antibodies cross react with human VEGF-B. The antibodies of the invention inhibit tumor growth in vivo in greater extent than Bevacizumab (Avastin
