Methods of treating a wart are provided which include: providing a heating device having a central zone and peripheral zone, sized to cover the wart and skin peripheral to the wart, and including a heat-generating material that undergoes an exothermic reaction when exposed to oxygen providing a liquid therapeutic adhesive comprising a volatile solvent, skin-compatible adhesive and therapeutic agent applying the liquid therapeutic adhesive to the skin peripheral to the wart or to the peripheral zone of the heating device initiating the exothermic reaction of the heat-generating material by exposure of the heat-generating material to oxygen applying the central zone of the heating device to contact the wart, thereby heating the wart and skin peripheral to the wart to an elevated skin temperature and maintaining the elevated skin temperature for a period of time, thereby creating an enclosed heated environment treating the wart and skin peripheral to the wart.
