Methods and products are disclosed for treating an inflammatory intestinaldisease in a mammalian subject in needthereof, or preventing or reducing a symptom of inflammatory intestinaldisease. These method include administering to thesubject a therapeutically effective dose of (i) an isolated AvrA protein orpolypeptide fragment thereof or (ii) a nucleic acid moleculeencoding the isolated AvrA protein or polypeptide fragment. Preferredinflammatory intestinal diseases include InflammatoryBowel Disease, Celiac Disease, and gastroenteritis.