SHUN PING, HUANG,黄舜平,黃舜平,SHEU, JYH HORNG,许志宏,許志宏,WEN, ZHI HONG,温志宏,溫志宏,TSAI, RONG KUNG,蔡荣坤,蔡榮坤
申请号：
TW105112654
公开号：
TWI581790B
申请日:
2016.04.22
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The present invention relates to a use of 4-(phenylsulfanyl)butan-2-one (4-PSB-2) for preparing pharmaceutical composition for protecting optic nerve, wherein the optical nerve is retinal ganglion cells (RGCs). The present invention has the ability of enhancing the protection effect of RGCs, preserving the visual function in optic nerve after crush injury, attenuating apoptosis in optic nerve after injury, and inhibiting the inflammatory responses in optic nerves after ON injury.本發明提供一種化合物4-(phenylsulfanyl)butan-2-one(4-PSB-2)用於製備治療視神經損傷之醫藥組合物的用途,其中該視神經為視網膜神經節。本發明之用途可提高視網膜神經節細胞之保護作用、保留視神經損傷後之視覺、減緩視神經損傷所引起的細胞凋亡現象、及抑制視神經損傷所引起細胞發炎反應。
