To provide a blood purification device and a blood purification system, capable of improving operability even in the case of using a blood purifier requiring a particular treatment condition or operation setting.SOLUTION: A blood purification device comprising a blood purifier for performing blood purification treatment by purifying a patient's blood and control means 13 for making operation for performing blood purification treatment or operation related to the blood purification treatment be performed on the basis of a predetermined treatment condition or operation setting comprises: registration means 14 capable of previously registering a treatment condition or operation setting corresponding to the blood purifier's performance, characteristic, or function; and changing means 15 capable of changing a treatment condition or operation setting to the treatment condition or operation setting registered by the registration means 14 depending on a blood purifier to be used in the blood purification treatment. The registration means 14 registers a treatment condition or operation setting depending on membrane area of the blood purifier to be used in the blood purification treatment.SELECTED DRAWING: Figure 1