IMIDAZOLES SUBSTITUES PAR ARYLE

• 收藏
• 分享

专利权人:

ST. JUDE CHILDREN'S RESEARCH HOSPITAL;ST. JUDE CHILDRENS RESEARCH HOSPITAL

发明人:

GUY, R. KIPLIN,ZHANG, YIQUN,YOUNG, BRANDON,DYER, MICHAEL,FINCH, KRISTIN,BASHFORD, DONALD,BHARATHAM, NAGAKUMAR,KRIWACKI, RICHARD,ROYAPPA, GRACE,MIN, LIE,FERREIRA, ANTHONY,MIN, JAEKI

申请号：

CA2813256

公开号：

CA2813256A1

申请日:

2011.09.30

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/