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CHIMERIC ANTIBODY RECEPTOR TO WHICH ANTI-COTININE ANTIBODY IS LINKED, AND USE THEREOF
专利权人:
发明人:
申请号:
EP16837312.4
公开号:
EP3339320A1
申请日:
2016.08.17
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention relates to chimeric antibody receptors with anti-cotinine antibodies linked, and use thereof. A T cell presenting the chimeric antibody receptor on the surface secretes interferon gamma specifically for a target molecule of a cotinine-conjugated binding molecule that is added together therewith and induces cell death of the cell expressing the target molecule by the T cell. On the contrary, by administering a cytotoxic agent conjugated with cotinine, cell death of the chimeric antigen receptor T cell is induced. Therefore, if necessary, a cytotoxic agent conjugated with cotinine can be administered to remove the chimeric antigen receptor T cells that have been already administered, thereby suppressing immune side effects due to hyperactivity of T cells. Thus, the chimeric antigen receptor to which the anti-cotinine antibody is linked can be effectively and safely used for the treatment of cancer.
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