Method of treating TDP-43 proteinopathies using hexachlorophene

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专利权人:

Umesh K. Jinwal

发明人:

Umesh K. Jinwal,Diego A. Peralta,Malathi Narayan

申请号：

US14742164

公开号：

US09844519B1

申请日:

2015.06.17

申请国别(地区):

US

年份:

2017

代理人:

摘要：

A method of treating TDP-43 proteinopathies such as Alzheimers disease, amyotrophic lateral sclerosis, and fronto-temporal lobar dementia is presented herein. It was found that administering hexachlorophene to cells expressing endogenous TDP-43 or overexpressing wild-type TDP-43 reduced accumulation of TDP-43 in the cells.

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