THE PRESENT INVENTION INCLUDES METHODS FOR THE INHIBITION OF POST-OPERATIVE ADHESION FORMATION BETWEEN TISSUE SURFACES IN A BODY CAVITY HAVING BEEN SUBJECTED TO A SURGICAL PROCEDURE, WHICH METHODS INVOLVE ADMINISTERING A HISTAMINE H4 RECEPTOR ANTAGONIST, SYSTEMICALLY, DIRECTLY TO TISSUE SURFACES IN THE BODY CAVITY, OR BOTH, AND TO DELIVERY VEHICLES AND COMPOSITIONS SUITABLE FOR USE FOR LOCAL, NON-SYSTEMIC ADMINISTRATION OF A DRUG TO THE BODY AND DIRECTLY TO TISSUE WITHIN A BODY CAVITY HAVING BEEN SUBJECTED TO A SURGICAL PROCEDURE.