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COMPOSITIONS AND METHODS OF TREATING INFLAMMATORY BOWEL DISEASE
专利权人:
Case Western Reserve University
发明人:
James E. Dennis,Thomas Kean,Inkap Ko
申请号:
US14591621
公开号:
US20150313945A1
申请日:
2015.01.07
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A method of treating a lymphocyte mediated inflammation in a subject including administering a therapeutically effective amount of a cell delivery composition to the subject, the cell delivery composition of the application including an immunosuppressive cell and a plurality of targeting moieties that bind to endothelial cell adhesion molecules expressed by endothelial cells as a result of a lymphocyte mediated inflammatory response in the subject, the targeting moieties coated on and linked to the immunosuppressive cell and enhancing adherence of the immunosuppressive cell to an endothelial cell at a site of lymphocyte mediated inflammation when administered to the subject systemically, wherein the cell delivery composition, suppresses lymphocyte mediated inflammation in the subject.
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中国工程科技知识中心
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