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1,2,3,4-tetrahydroquinoxaline compounds having glucocorticoid receptor binding activity
专利权人:
Santen Pharmaceutical Co.; Ltd.
发明人:
Mamoru Matsuda,Toshiyuki Mori,Kenji Kawashima,Minoru Yamamoto,Masatomo Kato,Miwa Takai,Masato Nagatsuka,Sachiko Kobayashi
申请号:
US13937447
公开号:
US08975256B2
申请日:
2013.07.09
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A 1,2,3,4-tetrahydroquinoxaline compound represented by the following formula:In the formula (1), R1 represents substituents such as a halogen, an alkyl, a cycloalkyl, an aryl or a heterocyclic group; p represents 0 to 5; R2 represents substituents such as a halogen, an alkyl, a hydroxyl or an alkoxy group; q represents 0 to 2; R3 represents substituents such as hydrogen, an alkyl, an alkenyl, an alkylcarbonyl or an arylcarbonyl group; R4 and R5 independently represent substituents such as hydrogen, a halogen, an alkyl, an alkenyl, an alkynyl, a cycloalkyl, an aryl or a heterocyclic group; R6 represents substituents such as hydrogen, an alkyl, an alkenyl, an alkynyl, a cycloalkyl, an aryl or a heterocyclic group; A represents an alkylene; R7 represents OR8, NR8R9, SR8, S(O)R8, S(O)2R8; R8 and R9 independently represent substituents such as hydrogen, an alkyl or an alkenyl; and X represents O or S.
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