The present invention relates to compositions and methods for treatment of disease. More particularly, the present invention relates to anti-IL-1ß and anti-IL-18 antibodies, including anti-IL-1ß and anti-IL-18 bispecific antibodies, and methods of treating disease using such antibodies.Cette invention concerne des compositions et des méthodes de traitement de maladies. Plus particulièrement, cette invention concerne des anticorps anti-IL-1β et IL-18, comprenant des anticorps bispécifiques anti-IL-1β et anti-IL-18, et des méthodes de traitement de maladies les utilisant.