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DERIVES DE DIBENZOFURANE COMME INHIBITEURS DE PDE-4 ET PDE-10
专利权人:
MATRIX LABORATORIES LTD.
发明人:
GOPALAN, BALASUBRAMANIAN,RAVI, DHAMJEWAR,SHRIKANT, HAVALE,SREEDHARA, SWAMY KESHAVAPURA HOSAMANE
申请号:
CA2663178
公开号:
CA2663178C
申请日:
2007.09.10
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The invention relates to heterocyclic compounds useful as phosphodiesteraseinhibitors(PDEs) in particular phosphodiesterase type 4 (PDE-4) and type 10 inhibitors(PDE-10)represented by formula (I), tautomeric forms, stereoisomers, diastereomers,enantiomers,appropriate N-oxides, pharmaceutically acceptable salts, pharmaceuticallyacceptable hydrates,pharmaceutically acceptable solvates, pharmaceutically acceptable compositionscontaining themand their use in treating allergic and inflammatory diseases and forinhibiting the production ofTumor Necrosis Factor (TNF-.alpha.).The compounds represented by general formula I are useful in the treatment ofallergicand inflammatory diseases including asthma, COPD, allergic rhinitis, allergicconjunctivitis,respiratory distress syndrome, chronic bronchitis, nephritis, rheumatoidspondylitis,ostheoarthritis, atopic dermatitis, eosinophilic granuloma, psoriasis,rheumatoid septic shock,ulcerative colitis, parkinson's disease; multiple sclerosis, chronicinflammation, Crohn'ssyndrome and other inflammatory conditions of lungs, eyes, joints, bowels,skin, heart andcentral nervous system (CNS).The invention also relates to a process for preparing the heterocycliccompounds of thegeneric formula (I).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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