This invention possesses immunity adjustment activity, it regards alternate D die and the annular peptide which includes L die amino acid. In addition as for this invention, it regards also the pharmacy constituent and the manner includes the said annular peptide in order which to deal with the disease.本発明は、免疫調節活性を保有する、交互のD型およびL型アミノ酸を含む環状ペプチドに関する。本発明はまた、該環状ペプチドを含む薬学的組成物および疾患を処置するための方法にも関する。