1. This note is in the field of genome alteration, especially in the field of targeted alteration of the genome of a hemoglobin cell. In the field of genome engineering, the current feature is targeted alteration of the genome of a hemoglobin cell.La presente descripción se encuentra en el campo de la modificación del genoma, particularmente la modificación dirigida del genoma de una célula hematopoyéticaThe present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.