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Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors
专利权人:
WILEX AG
发明人:
SPERL, STEFAN,BÜRGLE, MARKUS,SCHMALIX, WOLFGANG,WOSIKOWSKI, KATJA,CLEMENT, BERND
申请号:
ES04734821
公开号:
ES2550611T3
申请日:
2004.05.26
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compounds of the general formula I ** Formula ** where E means a group of ** Formula ** R3 means H, R5 means -OR6, -N (R6) 2, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl, unsubstituted or substituted, and R6 means H, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl, unsubstituted or substituted, or a cyclic moiety, each cyclic moiety being capable of carrying one or several substituents, selected from C1-C3-alkyl, C1-C3-alkoxy, halogen, -OR6,>; = O, -NO2, -CN, -COOR6, -N (R6) 2, -NR6COR6, -NR6CON (R6) 2 and -OCOR6, and each alkyl, alkenyl and alkynyl may be straight or branched chain, and carry one or more substituents, selected from halogen, -OR6, -OCOR6, -N (R6) 2, - NR6COR6, -NR6CON (R6) 2, COOR6, or a cyclic moiety, or salts of these compounds, as well as, where appropriate, supports, diluents and / or usual auxiliary agents from the pharmaceutical point of view, for use as a medicine.Compuestos de la fórmula general I**Fórmula** donde E significa un grupo de**Fórmula** R3 significa H, R5 significa -OR6, -N(R6)2, C1-C6-alquilo, C2-C6-alquenilo o C2-C6-alquinilo, no substituido o substituido, y R6 significa H, C1-C6-alquilo, C2-C6-alquenilo o C2-C6-alquinilo, no substituido o substituido, o un resto cíclico, pudiendo portar cada resto cíclico uno o varios substituyentes, seleccionados a partir de C1-C3-alquilo, C1-C3- alcoxi, halógeno, -OR6, >;=O, -NO2, -CN, -COOR6, -N(R6)2, -NR6COR6, -NR6CON(R6)2 y -OCOR6, y pudiendo cada alquilo, alquenilo y alquinilo ser de cadena lineal o ramificado, y portar uno o varios substituyentes, seleccionados a partir de halógeno, -OR6, -OCOR6, -N(R6)2, -NR6COR6, -NR6CON(R6)2, COOR6, o un resto cíclico, o sales de estos compuestos, así como, en caso dado, soportes, diluyentes y/o agentes auxiliares habituales desde el punto de vista farmacéutico, para empleo como medicamento.
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