FORMULATIONS DE MEDICAMENTS A BASE DE DERIVES PHOSPHORAMIDATE DE NUCLEOSIDES

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专利权人:

NUCANA PLC

发明人:

KENNOVIN, GORDON,GRIFFITH, HUGH

申请号：

CA3008751

公开号：

CA3008751A1

申请日:

2016.12.21

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

This invention relates to pharmaceutical formulations and formulation strategies of protides (phosphoramidate derivatives of nucleosides) and, in particular, protides useful in the treatment of cancer such as NUC-3373 (5-fluoro-2'-deoxyuridine-5'-0-[1-naphthyl (benzoxy-L-alaninyl)] phosphate) and NUC-7738 (3'-deoxyadenosine-5'-0-[phenyl(benzyloxy-L-alaninyl)] phosphate). In particular, the invention relates to formulations which comprise a polar aprotic solvent, for example dimethyl acetamide (DMA).

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