The invention relates to anti-cancer compositions comprising synergistically effective amounts of an extract of shark meat and an extract of a mushroom, in particular, compositions containing a shark meat extract and an extract from the Korean mushroom Phellinus linteus. The invention also relates to a method of treating or preventing cancer, particularly melanoma, using a composition of the invention.本發明係關於一種含協同有效劑量之鯊魚肉萃出物及蘑菇萃出物的抗癌組成物,更明確而言,此組成物含鯊魚肉萃出物及高麗蘑菇(俗稱桑黃,學名為裂蹄木層孔菌,Phellinus linteus)」萃出物。本發明亦係關於一種治療或預防癌症尤指黑色素瘤的方法,及本發明組成物的用途。