PROBLEM TO BE SOLVED: To provide a drug and a method for treating, preventing and diagnosing a disease by using a compound which specifically binds to and inhibits NKG2A in combination with a compound which binds to and inhibits human PD-1. An agent that neutralizes the inhibitory activity of human NKG2A for use in the treatment of cancer in human patients, wherein the treatment is (a) an agent that neutralizes the inhibitory activity of human NKG2. An agent that optionally neutralizes the inhibitory activity of the antibody and (b) human PD-1, and optionally administers an effective amount of each antibody to the patient. [Selection diagram] None【課題】トＮＫＧ２Ａに特異的に結合して阻害する化合物を、ヒトＰＤ－１に結合して阻害する化合物と組み合わせて使用する、薬剤、並びに疾患の処置、予防及び診断の方法の提供。【解決手段】ヒト患者のがんの処置で使用するための、ヒトＮＫＧ２Ａの阻害活性を中和する薬剤であって、前記処置は、（ａ）前記ヒトＮＫＧ２の阻害活性を中和する薬剤、任意選択で抗体および（ｂ）ヒトＰＤ－１の阻害活性を中和する薬剤、任意選択で抗体それぞれの有効量を前記患者に投与することを含む、薬剤。【選択図】なし
