William J. McBride,Christopher A. DSouza,Chien-Hsing Chang,David M. Goldenberg
申请号：
US12964132
公开号：
US08435539B2
申请日:
2010.12.09
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to methods and compositions for pretargeting delivery of therapeutic agents. In preferred embodiments, the pretargeting method comprises: a) administering a bispecific antibody with a first binding site for a disease-associated antigen and a hapten on a targetable construct b) administering a targetable construct comprising at least one therapeutic agent. In preferred embodiments, the bispecific antibody is made by the dock-and-lock (DNL) technique. In a more preferred embodiment, the targetable construct comprises one or more SN-38 moieties.
