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Sustained-release once-a-day oral dosage oxycodone formulations
专利权人:
EURO-CELTIQUE S.A.
发明人:
OSHLACK, BENJAMIN,PRATER, DEREK ALLAN,WRIGHT, CURTIS
申请号:
NZ58701002
公开号:
NZ587010A
申请日:
2002.05.02
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
The disclosure relates to a sustained-release oral dosage form for once-a-day administration comprising: a pharmaceutically acceptable sustained-release matrix comprising, as part of the sustained-release matrix, (a) an analgesially effective amount of oxycodone in the range from 1 mg to 640 mg of oxycodone or a pharmaceutically acceptable salt thereof, and (b) a sustained release material in an effective amount to render the dosage form suitable for once-a-day oral administration, the sustained-release matrix coated with a coating, wherein the dosage form provides a sustained release effect for at least about 24 hours and a mean C24/Cmax oxycodone ratio of 0.7 to 0.99 after once-a-day steady state oral administration to human patients.
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