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Methods for producing amino-substituted glycolipid compounds
专利权人:
Karsten Matthias Kragh;Rene Mikkelsen;Flemming Vang Sparsø;Anne Katherine Kjærsgaard Laursen;Lars Wiebe
发明人:
Flemming Vang Sparsø,Karsten Matthias Kragh,Lars Wiebe,Rene Mikkelsen,Anne Katherine Kjærsgaard Laursen
申请号:
US13574420
公开号:
US09045514B2
申请日:
2011.01.20
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A method of preparing a compound of formula (I): wherein: a first group selected from R1, R2 and R3 is an amino- or N-acylamino monosaccharide moiety, the acyl group having 1 to 6 carbon atoms, or an oligosaccharide chain comprising 2 to 4 monosaccharide moieties, at least one of which is an amino- or N-acylamino monosaccharide moiety; a second group selected from R1, R2 and R3 is a alkanoyl and alkenoyl acyl group having 3 to 40 carbon atoms; and a third group selected from R1, R2 and R3 is hydrogen, the method comprising contacting a monoacylglycerol, the acyl moiety thereof being a saturated or unsaturated acyl group having 3 to 40 carbon atoms, or an activated derivative thereof, with a source of amino- or N-acylamino monosaccharide moiety, or an activated derivative thereof, and, if required, a source of unsubstituted monosaccharide moiety, or an activated derivative thereof, optionally in the presence of a suitable catalyst or activating agent, is described.
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