Quinolone derivatives

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专利权人:

アステラス製薬株式会社

发明人:

恩田 健一,今村 健一郎,佐藤 史恵,森友 博幸,浦野 泰治,澤田 由紀,石橋 直樹,中西 慶太,横山 和宏,古川 重忠,百▲瀬▼ 和浩

申请号：

JP2009534371

公开号：

JP5564947B2

申请日:

2008.09.25

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

As a result of extensive studies on NAD(P)H oxidase inhibitors, the present inventors found that a quinolone derivative having, at the 2-position, an alkyl group substituted with a heteroatom or the like has an excellent NAD(P)H oxidase inhibitory activity, and accomplished the present invention. The compound of the present invention has a reactive oxygen species production inhibitory activity based on the NAD(P)H oxidase inhibitory activity, and therefore can be used as an agent for preventing and/or treating diabetes, impaired glucose tolerance, hyperlipidemia, fatty liver, diabetetic complications and the like.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/