A method includes performing a contrast enhanced computed tomography (CT) scan of tissue of interest of a subject, with an imaging system (100) having a radiation source (112) and a detector array (118), in which a peak contrast enhancement of the tissue of interest, a full range of motion of the tissue of interest, and an entire volume of interest of the tissue of interest are concurrently imaged during a single rotation of the radiation source and the detector array of the imaging system over an entire or a predetermined sub-portion of a breathing cycle.