UPENDER VELAPARTHI,CHETAN PADMAKAR DARNE,PEIYING LIU,MARK D. WITTMAN,BRADLEY C. PEARCE,ERIKA ARAUJO,BIRESHWAR DASGUPTA,JALATHI SURENDRAN NAIR,SAKTHI KUMARAN JANAKIRAMAN,CHANDRASEKHAR REDDY RACHAMREDDY
申请号：
ARP140104277
公开号：
AR098414A1
申请日:
2014.11.13
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
You are medically acceptable. These compounds inhibit the activity of quinase protein and make it an antineoplastic agent. 1. Claim 1: a compound characterized by formula (1),Or a pharmaceutically acceptable salt, in which case x is selected independently of O and NH； R1 is selected independently of carbohydrate, replaced by 1-5 r83099；The isomerization consists of carbon atom and 1-3 isomerized atoms selected from n.83088；e. O, s, changed to 1-5 r83099；R2 chooses the lease which is independent of (I) alternative F, Cl, Br, or74955；Cn, No. 7491； r7491；-C (3DO) NR RC₂₋₆ alkenyl substituted with 0-5 Rᵉ,Asphalt replaced by 0-5 r74977；1. Carbohydrates were replaced by carbon atoms in 1-8 r8311 and heteromorphic atoms selected from n, n8310 by 1-4；o. S, changed to 1-8 r8311；(II) cycliquil to 1-8 r8311；(III) cyclohexane, to 1-8 r8311；R3 7491,R3 degrees 7495；R3 degrees 7580,R3 degrees 7496；R³ᵉ and R³ᶠ are independently selected from H, CN, C₁₋₄ alkyl substituted with 1-3 R⁸,-C (3DO) OR-C (3DO) NR R-C (3DO) R-No. 7491； (= O) r7495；-No. 7491； (= O) or7495；-(ch8322) 691 - substituted 1-3r831222 and - (ch8322) 691 - isopropene for 1-3r831222；Alternatives, R3 7491 and R3 74955,o R y R o R y RThey are combined with carbon atoms to form a carbon thyroid or hetero helical ring, which is composed of carbon atoms and 1 to 4 hetero atoms selected from n or S. each hetero atom is replaced by 1-5 r831222；Alternatives, R3 7491 and R3 758080；O r3-74959 and r3-74966；Together, they form an aperiodic ring composed of carbon atoms and one to four heteromorphic atoms selected from n or s, and are replaced by 1-5r831222；R⁴ is independently selected from H, C₁₋₄ alkyl substituted with 0-3 Rᵉ,- (CH) CN - (CH) OR(CH) S (O) R- (CH) C (3DO) R- (CH) NR R- (CH) C (3DO) NR R- (CH) NR C (3DO) R- (CH) NR C (3DO) OR- (CH) OC (3DO) NR R- (CH) NR C (3DO) NR R- (CH) C (3DO) OR- (CH) S (O) NR R- (CH) NR S (O) NR R- (CH) NR S (O) R(ch8322) 691 - replace 0-3r7497y - (ch8322) 691 - isopropylene with 0-3r74979；R
