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BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS
专利权人:
GLAXOSMITHKLINE LLC
发明人:
QU, JUNYA,RIVERO, RALPH,SANCHEZ, ROBERT,TEDESCO, ROSANNA
申请号:
RSP20170140
公开号:
RS55662B1
申请日:
2011.09.23
申请国别(地区):
RS
年份:
2017
代理人:
摘要:
The invention relates to benzimidazole derivatives of formula (I) which modulate, notably inhibit the activity or function of the phosphoinositide 3-OH kinase family (PI3 kinases), suitably PI3K±, PI3K´, PI3K² and/or PI3K³. The invention further relates to these benzimidazoles for use in the treatment of disease states selected from autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries. Especially, the invention relates to PI3K² selective benzimidazoles for use in treating cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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