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Agents inducing apoptosis for the treatment of cancer and immune and autoimmune diseases
- 专利权人:
- ABBVIE INC.
- 发明人:
- HEXAMER, LAURA,DING, HONG,ELMORE, STEVEN W.,KUNZER, AARON R.,SONG, XIAOHONG,SOUERS, ANDREW J.,SULLIVAN, GERARD M.,TAO, ZHI-FU,WENDT, MICHAEL D.
- 申请号：
- ES12163746
- 公开号：
- ES2536090T3
- 申请日:
- 2010.01.15
- 申请国别(地区):
- ES
- 年份:
- 2015
- 代理人:
- 摘要：
- A compound or a therapeutically acceptable salt, where the compound is selected from the group consisting of: - Group 1: 4- [4- (3,3-diphenylprop-2-enyl) piperazin-1-yl] -N- [ (3-nitrophenyl) sulfonyl] benzamide N - [(2-bromophenyl) sulfonyl] -4- (4 - {[2- (4-chlorophenyl) cyclohex-1-en-1-yl] methyl} piperazin-1-yl )benzamide； N - [(3-bromophenyl) sulfonyl] -4- (4 - {[2- (4-chlorophenyl) cyclohex-1-en-1-yl] methyl} piperazin-1-yl) benzamide； N - [(4-bromophenyl) sulfonyl] -4- (4 - {[2- (4-chlorophenyl) cyclohex-1-en-1-yl] methyl} piperazin-1-yl) benzamide； 4- {4 - [(4'-chloro-1,1'-biphenyl-2-yl) methyl] piperazin-1-yl} -N - [(3-nitrophenyl) sulfonyl] benzamide； 4- {4 - [(4'-chloro-1,1'-biphenyl-2-yl) methyl] piperazin-1-yl} -N- (phenylsulfonyl) benzamide； 2- (benzyloxy) -4- {4 - [(4'-chloro-1,1'-biphenyl-2-yl) methyl] piperazin-1-yl} -N - [(3-nitrophenyl) sulfonyl] benzamide； 4- {4 - [(4'-chloro-1,1'-biphenyl-2-yl) methyl] piperazin-1-yl} -NN - [(3-nitrophenyl) sulfonyl] -2- (2-phenylethoxy) benzamide； 4- {4 - [(4'-chloro-1,1'-biphenyl-2-yl) methyl] piperazin-1-yl} -N - [(3-nitrophenyl) sulfonyl] -2-phenoxybenzamide； 4- {4 - [(4'-chloro-1,1'-biphenyl-2-yl) methyl] piperazin-1-yl-2-phenoxy-N- (phenylsulfonyl) benzamide； N - [(4-bromophenyl) sulfonyl] -4- {4 - [(4'-chloro-1,1'-biphenyl-2-yl) methyl] piperazin-1-yl} benzamide； 4- [4- (1,1'-Biphenyl-4-ylmethyl) -3-isopropylpiperazin-1-yl] -N- (phenylsulfonyl) benzamide； 4- {4 - [(4'-chloro-1,1'-biphenyl-2-yl) methyl] piperazin-1-yl} -N - [(3-nitrophenyl) sulfonyl] -2- (phenylthio) benzamide； 2- (benzylamino) -4- {4 - [(4'-chloro-1,1'-biphenyl-2-yl) methyl] piperazin-1-yl} -N - [(3-nitrophenyl) sulfonyl] benzamide； 2-benzyl-4- {4 - [(4'-chloro-1,1'-biphenyl-2-yl) methyl] piperazin-1-yl} -N - [(3-nitrophenyl) sulfonyl] benzamide； 4- {4 - [(4'-chloro-1,1'-biphenyl-2-yl) methyl] piperazin-1-yl} -N - [(4-nitrophenyl) sulfonyl] benzamide； 4- {4 - [(4'-chloro-1,1'-biphenyl-2-yl) methyl] piperazin-1-yl} -N - [(4-hydroxyphenyl)
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
