Lambert, John,O'Leary, James J.,Schindler, Joanne Elizabeth Sarah,Weitman, Steven,Qin, Albert,OLeary, James J.
申请号：
AU2010310577
公开号：
AU2010310577A1
申请日:
2010.10.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
This invention relates to a method of treatment and dosing regimen for treating disease, such as cancer and mammalian tumors, wherein therapy with a cytotoxic drug is suitable, by the administration of an antibody-toxin conjugate, such as a maytansinoid toxin, by infusion at an initial infusion rate of 1 mg/min or lower on a schedule selected from the group consisting of: (1) an amount of at least about 90 mg/m on day 1 and day 8, every three weeks； (2) at least an amount of about 30 mg/m on day 1, day 2 and day 3, every three weeks； (3) at least an amount of about 45 mg/m on day 1, day 8, and day 15, every 4 weeks； and (4) at least an amount of about 45 mg/mon day 1, day 8 and day 15, every 3 weeks.
