The present disclosure describes novel standardized citrate replacement fluidsolutions and a standardized dialysate solution for use with CRRT methods. Thestandardized citrate replacement fluid solutions and standardized dialysatesolutions do not require modification based on the clinical status of theindividual patients. The use of the standardized solutions described hereinoffers significant advantages over the prior art solutions used in CRRT. Thepresent disclosure describes superior metabolic and electrolyte control andsignificantly increased dialyzer patency in: (a) 24 intensive care unit (ICU)patients with ARF using a 0.67% trisodium citrate replacement fluid solution,and (b) 32 ICU patients with ARF using a 0.5% trisodium citrate replacementfluid solution. Both groups were treated with Bicarbonate-25 dialysate andachieved effluent rates of 35 mL/kg/hr.