Obshchestvo s ogranichennoi otvetstvennostiu "Sovremennye meditsinskie tekhnologii"
发明人:
Krivoviaz Natalia Viktorovna (RU),Кривовяз Наталья Викторовна (RU),Khachin Stepan Vladimirovich (RU),Хачин Степан Владимирович (RU),Evstigneeva Evgeniia Evgenevna (RU),Евстигнеева Евгения Евгеньевна (
申请号：
RU2019135547
公开号：
RU0002723737C1
申请日:
2019.11.05
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to a method for applying biopolymer coating from chitosan, preventing ingrowth of stent-endoprosthesis into walls of hollow organ and device with biopolymer coating for introduction into hollow organs to increase their lumen, in particular, to antimigration stent-endoprosthesis. Method of applying a chitosan coating on an antimigration stent-endoprosthesis is characterized by dissolving chitosan in an acid, immersing the stent into the obtained solution, fixing the obtained coating and drying. Method comprises preparing 5 wt% solution of chitosan in 5 % aqueous solution of citric acid, stents-endoprosthesis are placed on a holder frame, made with possibility of rotation around its axis of symmetry, frame of holder with stents is lowered into solution of chitosan in acid and rotating frame is maintained in obtained solution for 3 minutes. Then the frame is immersed in 10 % water solution of triethanolamine for 5 minutes, dehydrated by immersion into pre-cooled ethanol with supersaturated sodium hydroxide for 30 minutes, and dried in vacuum for 1 hour until complete evaporation of solvent. Antimigratic stent-endoprosthesis for hollow organs is made of alloy with shape memory, with possibility of change of configuration when hollow organ is introduced into cavity. Stent-endoprosthesis contains the sections made with possibility of their opposite unwinding. Stent-endoprosthesis is made in the form of a hollow mesh cylinder formed by an interlacing of wire from alloy with memory of the form and consists of alternating belts of a grid of two types: belt of the first type, consisting of one row of compressed wire grid cells, uniformly expanding when heated in transverse direction, belt of the second type, consisting of one row of mesh squeezed in compressed condition of wire mesh, swirled relative to longitudinal stent axis and untwisted at heating in place of installation. Each next belt of wire cells of the
