MYCOBACTERIUM COMPRISING EXPRESSION VECTOR WITH TWO AUXOTROPHIC SELECTION MARKERS AND ITS USE AS VACCINE

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专利权人:

发明人:

Joan Joseph,Narcis Saubi Roca

申请号：

US14424545

公开号：

US20150211012A1

申请日:

2013.07.02

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The invention relates to polynucleotides and recombinant cell strains comprising the polynucleotides and the uses thereof for the delivery of the polypeptides encoded by the polynucleotides to a subject in need thereof. In particular, the invention refers to polynucleotides comprising a polypeptide of interest, auxotrophy-complementing genes and the use thereof in a mycobacterial double auxotrophic host cell to achieve the stable expression of the polypeptide of interest by using an antibiotic-free plasmid selection system.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/