PROBLEM TO BE SOLVED: To provide a nonhuman animal that does not cause media thickening or hypertension even when angiotensin II is administered.SOLUTION: The present invention provides a nonhuman animal in which the functions of TRPV2 (transient receptor potential, vanilloid family type 2) are inhibited specifically to smooth muscle more specifically, a nonhuman animal in which the expression of all or part of genes encoding TRPV2 is inhibited specifically to smooth muscle.SELECTED DRAWING: Figure 4COPYRIGHT: (C)2019,JPO&INPIT【課題】アンジオテンシンIIを投与しても、中膜肥厚及び高血圧症を生じない非ヒト動物を提供する。【解決手段】平滑筋特異的にTRPV2(transient receptor potential, vanilloid family type 2)の機能を抑制した非ヒト動物による。より具体的には、平滑筋特異的にTRPV2をコードする遺伝子の全部又は一部の発現を抑制してなる非ヒト動物による。【選択図】図4
