Martina Kalle;Nils Martin Malmsten;Artur Schmidtchen;Björn Ulrik Walse;Victoria Rydengard;Praveen Papareddy
发明人:
Martina Kalle,Nils Martin Malmsten,Praveen Papareddy,Victoria Rydengard,Artur Schmidtchen,Björn Ulrik Walse
申请号：
US13497195
公开号：
US20120189673A1
申请日:
2010.09.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from a naturally occurring protein which modulates blood coagulation, or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant or derivative thereof, for use in the treatment or prevention of inflammation and/or excessive coagulation of the blood. Related aspects of the invention provide isolated polypeptides comprising or consisting of an amino acid sequence of SEQ ID NOs: 1 to 11, or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant or derivative thereof which exhibit an anti-inflammatory and/or anti-coagulant activity, together with isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of inflammation and/or excessive coagulation.
