CHILDRENS MEDICAL CENTER CORPORATION;CHILDREN'S MEDICAL CENTER CORPORATION
发明人:
MALLEY, RICHARD,LU, YINGJIE,ZHANG, FAN
申请号：
CA2835630
公开号：
CA2835630A1
申请日:
2012.05.11
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from S. aureus and fusion protein comprising non-hemolytic variant of alpha-hemolysin and a biotin-binding domains. Immunogenic compositions comprising the proteins are also disclosed and use of such immunogenic compositions for inducing an immune response or for vaccinating a subject are also disclosed.
