Provided herein are T cell receptor (TCR) fusion proteins (TFPs) having specificity for more than one tumor cell associated antigen, T cells engineered to express one or more TFP, and methods of use thereof for the treatment of diseases, including cancer.本文提供對一種以上腫瘤細胞相關抗原具有特異性之T細胞受體(TCR)融合蛋白(TFP)、經工程改造成表現一或多種TFP之T細胞,以及使用其治療包括癌症在內之疾病的方法。