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EFFECTIVE COMBINATION OF HUMAN BONE MARROW MESENCHYMAL STEM CELLS AND MINOCYCLINE IN MULTIPLE SCLEROSIS
专利权人:
CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATIONFOUNDATION
发明人:
JEUN, SIN SOO,전신수,RYU, CHUNG HEON,유충헌,JEUN, SIN SOOKR,RYU, CHUNG HEONKR
申请号:
KR1020130060458
公开号:
KR1014559330000B1
申请日:
2013.05.28
申请国别(地区):
KR
年份:
2014
代理人:
摘要:
The present invention relates to an administration of both human bone marrow mesenchymal stem cells (hBM-MSCs) and Minocycline. The Minocycline improves a clinical magnitude of multiple sclerosis, exhibits good effects for anti-inflammation, nerve protection, and long-term use, yet has toxicity in CNS. The hBM-MSCs have shown immunity adjusting functions and nerve protecting functions. Compared to when Minocycline or hBM-MSCs are individually used, a remarkable decrease is exhibited in a clinical score when both Minocycline and hBM-MSCs are administrated. Moreover, when both Minocycline and hBM-MSCs are administrated, immunity adjusting effects are reinforced, and inflammatory cytokines (IFN-γ, TNF-α) are controlled. In contrast, anti-inflammatory cytokines (IL-4, IL-10) are increased. Furthermore, when both Minocycline and hBM-MSCs are administrated, the number of dead cells is remarkably decreased through TUNEL coloring compared to individual administration. When both Minocycline and hBM-MSCs are administrated, provided is a protocol of a new technique for treating multiple sclerosis.본 발명은 hBM-MSCs과 Minocycline을 병용투여에 관한 것으로서, Minocycline은 다발성경화증의 임상적 심각도를 개선하며, 항염증, 신경보호효과 및 장기사용에 좋은 내성을 보이는 반면 CNS에 독성이 있다. hBM-MSCs(human bone marrow mesenchymal stem cells)는 EAE에서 면역조절능력과 신경보호능력을 보여 왔다.본 발명은 Minocycline 또는 hBM-MSCs를 개별적으로 사용한 경우에 비해서 병용투여한 경우 면역점수(clinical score)에서 현저한 감소를 나타냈다. 더욱이 hBM-MSCs과 Minocycline의 병용투여는 면역조절효과를 강화하며, 전염증 사이토카인(IFN-γ, TNF-α)를 억제하고, 역으로 항염증 사이토카인(IL-4, IL-10)을 증가시킨다. 또한 TUNEL 염색을 통해 개별투여에 비하여 병용투여한 경우 사멸세포의 수가 현저하게 감소한 것을 확인하였다.hBM-MSCs과 Minocycline의 병용투여는 다발성경화증의 치료를 위한 새로운 방법의 프로토콜을 제공한다.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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